Aug 28
Dr.Yibing Shan Seminar

New insight into EGFR signaling--molecular dynamics simulations as a new tool for structural biology

In hope to convey the notion that molecular dynamics simulation is increasingly a legitimate tool of structural biology capable of non-derivative work, we will discuss the new insight we obtained from studying the structural basis of the signaling of epidermal growth factor receptor (EGFR) using molecular dynamics simulations supported by experimental work. We will discuss the conformational dynamics of the extracellular and the intracellular modules of EGFR that allows communication across the membrane, the mechanism behind the oncogenecity of many EGFR cancer mutations, and the crucial role of higher-order oligomers in normal EGFR signaling. 

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